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Rectangular ATX motherboard in dark grey with silver heatsinks and black PCIe slots

MSI

MSI X399 SLI PLUS AMD motherboard Socket TR4

SKU CH-3W54-M88FD

Socket TR4 board for AMD Ryzen Threadripper with four-channel DDR4 up to 3600 MHz, four PCIe 3.0 x16 slots, eight SATA ports, three M.2 interfaces, Intel I211 LAN.

  • ProcessorAMD Ryzen Threadripper processor with TR4 architecture suppo
  • ChipsetAMD X399
  • CPU socketSocket TR4
  • Supported memorySupport four-channel DDR4 DDR4 3600 + (OC)/3466 (OC)/3333 (O
  • Max supported RAM128 GB
  • PCI slots4 PCIe 3.0 x16 slots 2 PCIe 2.0 x1 slots
  • Quad-channel DDR4 up to 3600 MHz for high memory bandwidth
  • 128 GB maximum capacity handles large workloads
  • Four PCIe 3.0 x16 slots enable multi-GPU configurations
  • Realtek ALC1220 delivers 7.1 channel audio
  • Intel I211 provides Gigabit LAN connectivity

Socket TR4 platform

The MSI X399 SLI PLUS motherboard pairs the AMD X399 chipset with a Socket TR4 interface for Ryzen Threadripper processors. Four-channel DDR4 support scales up to 128GB across a wide OC frequency range from 2133MHz to 3600MHz. Four PCIe 3.0 x16 slots and two PCIe 2.0 x1 slots give multi-GPU and add-in card flexibility for workstation builds.

Sustained workload behaviour

The X399 chipset and four-channel memory architecture keep bandwidth high during long render or compute sessions. Eight SATA III ports and three M.2 interfaces maintain storage throughput without throttling. Realtek ALC1220 audio and Intel I211 Gigabit LAN operate independently of the CPU, so background encoding or network transfers do not compete for processor resources.

Pre-order compatibility checks

Verify that your Threadripper CPU uses the TR4 socket and that your cooler mounting matches the platform. Confirm the power supply delivers the required EPS connectors for the board. Ensure the chassis can accommodate an ATX form factor and that rear I/O cut-outs align with USB 3.1 Gen2 Type-A, Type-C, S/PDIF and LAN ports.

How it compares

Measured against everything we stock in Motherboards for AMD CPUs, at today’s prices. Recalculated every night.

Price $275.99
Pricier than about 54% of the 1,906 comparable items (median $224.49).

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Specifications

Product
Brand nameMSI
Product lineMSI X399 SLI PLUS
Model nameMSI X399 SLI PLUS
Processor
ProcessorAMD Ryzen Threadripper processor with TR4 architecture support
CPU socketSocket TR4
ChipsetAMD X399
Memory
Supported memorySupport four-channel DDR4 DDR4 3600 + (OC)/3466 (OC)/3333 (OC)/3200 (OC)/3066 (OC)/2933 (OC)/2800 (OC)/2667 (OC)/2400/2133 MHz memory
Max supported RAM128 GB
Storage
SATA and RAID support3XM.2 interface, 8xSATA III interface
Audio & video
Audio chipRealtek ALC1220 decoding chip
- 7.1 channel high-quality sound effects
- Supports S/PDIF output
Connectivity
Ethernet controller1 Intel I211 Gigabit network interface card
Ports & slots
PCI slots4 PCIe 3.0 x16 slots
2 PCIe 2.0 x1 slots

Questions about this item

How much power does the board itself draw when a Threadripper CPU is running all day?

The motherboard does not publish a standalone power-draw figure; total system consumption depends on the Threadripper model, memory kit and attached drives.

Which cooler mounting pattern and memory kit are required before this board will post?

You need a TR4-compatible cooler and a four-channel DDR4 kit up to 128 GB; the board accepts speeds from 2133 MHz to 3600 MHz (OC).

Will my older SATA SSDs and PCIe 2.0 expansion cards work in the available slots?

Eight SATA III ports support legacy SATA drives, and two PCIe 2.0 x1 slots accept older x1 cards; four PCIe 3.0 x16 slots handle newer GPUs.

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