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Large EEB motherboard with twelve memory sockets and four full-length PCIe slots, dark metallic finish with angular heatsinks

ASUS

ASUS ROG DOMINUS EXTREME Intel C621 3647 LGA EEB Motherboard

SKU CH-538C-CTAGG

Supports Xeon W-3175X with 12 DDR4 slots up to 192GB, four PCIe 3.0 x16, dual 10Gbps and 1Gbps LAN, Wi-Fi 802.11 and SupremeFX audio

  • ProcessorSupport to Xeon W-3175X
  • ChipsetIntel C621
  • Form factorEEB
  • CPU socketLGA 3647
  • Memory slot count12 × 288pin (DDR4)
  • Supported memorySupport up to DDR4 4200(O.C.)
  • Supports Xeon W-3175X for extreme workstation performance
  • 12 DDR4 slots enable up to 192 GB six-channel memory
  • Four PCIe 3.0 x16 slots offer flexible multi-GPU configurations
  • Dual 10 Gbps and 1 Gbps LAN plus Wi-Fi 802.11 for high-speed networking
  • SupremeFX S1220 audio delivers 120 dB SNR playback and 113 dB SNR recording

Designed for Xeon W-3175X workstations

This EEB motherboard pairs the Intel C621 chipset with an LGA 3647 socket to support the Xeon W-3175X processor. Twelve 288-pin slots provide six-channel DDR4 memory up to 192 GB with XMP 3.0 and ECC capability. Dual 10 Gbps and 1 Gbps LAN plus Intel Wireless-AC 9260 give high-speed wired and wireless connectivity. SupremeFX S1220 audio delivers 120 dB SNR playback and 113 dB SNR recording.

Replaces standard ATX workstation boards

The EEB form factor adds four PCIe 3.0 x16 slots configurable as x16/x16/x16 or x16/x8/x16/x8 alongside a legacy PCI slot. Six SATA 6 Gb/s ports and two ROG DIMM.2 modules accept M-key drives in 2242, 2260, 2280 and 22110 lengths running at PCIe 3.0 x4. This density suits multi-GPU compute, large memory capacity and high-speed storage arrays that exceed typical ATX limits.

Verify EEB case clearance and power delivery

Confirm the chassis accommodates the EEB dimensions and provides sufficient 12 V current for the CPU and six-channel memory. Ensure the power supply includes the required EPS connectors for the 3647 socket. Check that cooling solutions clear the DIMM.2 modules and U.2 connectors. Validate operating-system support for the AQC107 and I219-LM network controllers and the S1220 audio codec.

How it compares

Measured against everything we stock in Motherboards for Intel CPUs, at today’s prices. Recalculated every night.

Price $865.99
Pricier than about 92% of the 2,965 comparable items (median $97.99).

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Specifications

Product
Brand nameASUS
Model nameROG DOMINUS EXTREME
Processor
ProcessorSupport to Xeon W-3175X
CPU socketLGA 3647
ChipsetIntel C621
Memory
Memory slot count12 × 288pin (DDR4)
Supported memorySupport up to DDR4 4200(O.C.)
Max supported RAM192 GB
Memory channelsSix Channel
Memory profilesIntel XMP 3.0
ECC supportYes
Storage
SATA ports6 x SATA 6Gb/s
Audio & video
Sound channelsROG SupremeFX 8-Channel High Definition Audio CODEC S1220
- Supports : Jack-detection, Multi-streaming, Front Panel Jack-retasking
- High quality120dBSNR stereo playback outputand113dBSNR recording input
- SupremeFX Shielding Technology
- Supports up to 32-Bit/192 kHz playback *2
Audio Feature :
- Optical S/PDIF out port(s) at back panel
- Sonic Radar III
- Sonic Studio III + Sonic Studio Link
Connectivity
Ethernet controllerAQUANTIA AQC107
Second LAN controllerIntel I219-LM
Maximum network speed10 Gbit/s + 1 Gbit/s
Wi-Fi standardIntel Wireless-AC 9260
Wi-Fi 802.11 a/b/g/n/ac
Supports dual band frequency 2.4/5 GHz
Supports MU-MIMO
Supports channel bandwidth: HT20/HT40/HT80/HT160. Up to 1.73 Gbit/s transfer speed
Bluetooth support5.0
Ports & slots
PCIe 3.0 x16 slots4 x PCIe 3.0 x16 (x16/x16/x16, x16/x8/x16/x8)
PCI slots1 x PCI Slot
Ethernet port1 x RJ45
USB 3.1 ports1 x USB 3.1
Onboard USB headers2 x USB 3.1 Gen 1(up to 5 Gbit/s) connector(s) support(s) additional 4 USB 3.1 Gen 1 port(s)
2 x USB 2.0 connector(s) support(s) additional 4 USB 2.0 port(s)
Size & build
Form factorEEB
Width and length14.0 in × 14.0 in
In the box
In the boxAccessories:
User's manual
1 x ROG logo plate sticker
4 x M.2 Screw Package
1 x CPU installation tool
1 x ASUS 2T2R dual band Wi-Fi moving antennas (Wi-Fi 802.11 a/b/g/n/ac compliant)
1 x Fan Extension Card II (6 × 4-pin Chassis Fan connectors, 3 x RGB headers, 3 × 2-pin Thermal sensor header)
1 x Fan Extension Card II power cable
1 x Fan Extension Card II NODE connector cable
1 x Fan Extension Card II screw package
1 x SLI HB BRIDGE (2-WAY-L)
1 x Q-Connector
1 x ROG Logo Sticker(s)
1 x Extension Cable for RGB strips (80 cm)
1 x Extension cable for Addressable LED
3 x Thermistor cable
More details
BIOS2 × 128 Mb Flash ROM, UEFI AMI BIOS, PnP, SM BIOS 3.1, ACPI 6.1, Multi-language BIOS, ASUS EZ Flash 3, CrashFree BIOS 3, Secure Erase, User Profile, F11 EZ RAID Wizard, F6 Qfan Control, F3 My Favorites, Last Modified log, F12 PrintScreen, , F4 AURA ON/OFF and F9 Search

Questions about this item

What size case and power connectors does the EEB form factor and 12 memory slots require?

The EEB board needs a chassis that accepts the larger EEB footprint and a PSU with a 24-pin ATX plus two 8-pin EPS connectors to feed the 12 DDR4 slots and CPU.

Which slot does the ROG DIMM.2 module plug into and what step is often missed?

Insert the ROG DIMM.2 module into a DDR4 DIMM socket, not an M.2 slot, then enable the CPU_DIMM.2 option in BIOS so the 2242/2260/2280/22110 drives are detected.

When should the Wi-Fi 9260 antennas be re-seated or the module swapped?

Re-seat the external antennas if 2.4/5 GHz signal drops or 1.73 Gbps throughput falls; replace the Intel Wireless-AC 9260 module if firmware updates no longer restore link stability.

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